Chemical composition and biological properties of Ipomoea procumbens

Ipomoea procumbens

ter, 04 dez 2018

Publicado por

Author:

Batiga, Saadia 1  ;  Valli, Marilia 2 ;  Zeraik, Maria L. 3 ;  Fraige, Karina 2 ;  Leme, Gabriel M.2  ;  Pitangui, Nayla S.4 ;  Almeida, Ana Marisa F.4 ;  Michel, Sylvie 1  ;  Young, Maria Claudia M.5 ;  Bolzani,  Vanderlan 2


Abstract:

Natural products have been the most valuable source of chemical compounds in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. Brazil has an exceptionally rich biodiversity, and a valuable source of secondary metabolites that can be useful for the development of bioproducts. Ipomoea species, Convolvulaceae, are mostly found in tropical and sub-tropical regions, including South America and many are used for nutritional and medicinal purposes. Ipomoea procumbens Mart. & Choisy is endemic from South America, and this is the first study reported on the chemical composition and biological activities of this species. The present work reports the tentatively identification of natural products present in the extracts using a high performance liquid chromatography–high resolution mass spectrometry method. Additionally, the antioxidant and antifungal biological activities of the leaves, roots and steams extracts and fractions of this species were evaluated. While for the antioxidant activity the hydromethanol fractions (leaves, stem and roots) were more active, the methanol fractions of leaves and stem provided better results for the antifungal assay.


1  Laboratory of Pharmacognosy, University of Paris Descartes UMR CNRS, Faculty of Pharmacy, Paris, France

2  Department of Organic Chemistry, Nucleus of Bioassays, Biosynthesis and Ecophysiology of Natural Products, Institute of Chemistry, São Paulo State University, Araraquara, SP, Brazil

3  Chemistry Department, State University of Londrina, Londrina, PR, Brazil

4  Department of Clinical Analysis, Clinical Mycology Laboratory, Faculdade de Ciências Farmacêuticas, São Paulo State University – UNESP, Araraquara, SP, Brazil

5  Institute of Botany, Secretariat of Environment of São Paulo State, Água Funda, São Paulo, SP, Brazil


Link para o artigo completo:    https://www.sciencedirect.com/science/article/pii/S0102695X18302230

 

 

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