Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam

Vanderlan - Eugenia jambolana Lam 15mar19

sex, 15 mar 2019

Publicado por


Borges, Maiara S. [1] ; Biasetto, Carolina R. [1] ; Chapla, Vanessa M. [2] ; Ebrahimi, Samad N. [3] ; Costa, Mayra F. [1] ; Bolzani, Vanderlan S. [1] ; Araujo, Angela R. [1]


A new compound named methyl (6S,7S,2E,4E)-6,7-dihydroxy-4,6-dimethyl octanoate was isolated from Saccharicola sp. using high performance liquid chromatography-solid phase extraction-transfer tube (HPLC-SPE-TT), together with four known compounds, fusaric acid, trans-4-hydroxymellein, thymidine and adenosine. Saccharicola sp. was isolated from the stems of Eugenia jambolana Lam. (Myrtaceae) as endophytic fungus. The structure of this novel substance was established based on its spectroscopic data, including 1 H and 13C nuclear magnetic resonance (NMR), 2D NMR techniques and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). This paper deals with the first report of its kind on this compound in Saccharicola sp.

1  Institute of Chemistry, São Paulo State University (Unesp), 14800-060 Araraquara-SP, Brazil

2  Federal University of Tocantins (UFT), Química Ambiental, 77402-970 Gurupi-TO, Brazil

3  Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, 1983963113 Evin, Tehran, Iran

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