My main lines of research in CIBFar are: medicinal chemistry and planning of drugs, with emphasis in neglected diseases and cancer. The works concentrate in enzyme kinetic and mechanism of reactions; design of enzyme inhibitors and receptor ligands; biochemical and biological assays; SAR studies; molecular modeling of drugs; generation of databases and pharmacokinetic studies.
My main lines of research in CIBFar are: Prospection of bioactive secondary metabolites, with focus in species of Casearia and Cryptocarya, with cytotoxic, anti-inflammatory, antiulcer, antiparasitic action, etc. Establishment of analytical methods for qualitative analysis in complex mixtures for metabolomic studies and desreplication. Optimization of conditions for large-scale production of active metabolites.
Since August / 2009, he has been Researcher at the the Brasilian Biosciences National Laboratory (LNBio), in the Brasilian Center for Research in Energy and Materials (CNPEM), developing research in the area of Tumor Metabolic Adaptation. Between 2010 and 2014, was coordinator of the D03B-MX1 line of macromolecular crystallography at the Brasilian Synchrotron Light Laboratory (LNLS). He holds a bachelor's degree in Physics (2000) and a Master's degree (2003) and a Ph.D. (2006) in Biomolecular Physics from the São Carlos Institute of Physics, University of São Paulo (IFSC / USP). Background: Structural Biology with emphasis on Protein Crystallography. Performance: Basic Research in Tumor Metabolism Link to Google Scholar Citations.
My main lines of research in CIBFar are: Organic synthesis; chemistry of natural products; chemistry and bioactivity of endophytic fungi associated with vegetal species of Cerrado and Mata Atlântica, in the search for bioactive metabolites.
My main lines of research in CIBFar are: development of new methodologies for synthesis of Natural Products and analogues, using the concepts of Green Chemistry, as asymmetric organocatalysis and solvents and alternative energy sources. The synthesized compounds are evaluated against several biological assays, including antiparasitic and anticancinogen.
My main lines of research in CIBFar are: Our mission is the functional organic substance synthesis with potential application in the pharmaceutical and/or medicinal area. We search to develop new methodologies that allow to access the new synthetic processes, valuing aspects such as: ambient practicality, efficiency, economy and environmental aspects, with emphasis on the use of palladium in homogeneous catalysis enantioselective.
My main lines of research in CIBFar are: Search of natural assets of agropecuary interest of Minas Gerais and São Paulo Flora. Chemical study of fungi associated with seaweed. Chemistry of the Natural Products with emphasis in: antioxidants, chemoprevention, bioprospecting in Brazilian plants of Cerrado, Mata Atlantica and Amazônia and sustainable use of biodiversity; Standardization and validation biological assays.
My main lines of research in CIBFar are: antimicrobial peptides: applications and mechanism of action. Bioconjugates containing peptides in the search for new active molecules against cancer.
It investigates, through animal models, the molecular, neuroendocrine and neurochemical mechanisms related to the dependence on psychoactive substances of abuse. It works with models of behavioral sensitization, self-management and place-based preference. In addition to investigating the influence of age and stress on the development of dependence. In the National Institute on Drug Abuse (NIDA / NIH), Baltimore, MD - USA (2011-2014) worked with viral vectors, trangenic animals and flow cytometry to identify neural aterries related to relapse to drug use in neural ensembles. He is the author of two book chapters on neuropsychopharmacology and chapters in pharmacology textbooks. Has relevant work in the area of dependency. And he received the Return Home Program award from the International Brain Research Organization.
My main lines of research in CIBFar are: Anti-symmetrical total synthesis of natural products and biological active molecules using small polifunctionalized molecules (Morita-Baylis-Hillman adducts) as substrate. Mechanistic study of Morita-Baylis-Hillman through mass spectrometry. Design, synthesis and evaluation of new antitumor, anti-inflammatory and anti-bacterial agents.
My main lines of research in CIBFar are: Applications of structural biology and medicinal chemistry in the development of new drugs, with particular emphasis in Brazilian endemic diseases. Integrated use of techniques of molecular biology, biochemistry, protein crystallography, molecular modeling and cellular biology in rational planning of bioactive molecules.
My main lines of research in CIBFar are: Development of dereplication techniques making use of RMN and computational models aiming at the elucidation of secondary metabolites in high complexity molecular extracts. Application of multivariate analysis and chemometric tools in the detection of biologically relevant compounds.
My main lines of research in CIBFar are: investigate the mechanism of resistance to antibiotics in positive and negative Gram bacteria of clinical interest, search for new compounds that have activity against multiresistant bacteria and perform tests to find compounds capable of destroying biofilms these bacteria.
My main lines of research in CIBFar are: 1) Interaction of bioactive peptides and peptide sequences of proteins involved in physiopathology, with systems models of membranes and cells, investigated for different spectroscopic methods. 2) Education and Diffusion of Sciences: a) Development and evaluation of educational resources; b) Interaction University and Basic Education in the continued education of teachers.
My main lines of research in CIBFar are: Synthesis of compounds for the treatment of Malaria and Chagas Disease in collaboration with the Drugs for Neglected Diseases initiative (DNDi, www.dndi.org) and with the Medicines for Malaria Venture (MMV, www.mmv.org).
Graduated in Biological Sciences from the Universidade Federal de Santa Catarina (1993-1997) and PhD in Sciences. Concentration Area: Physiology, Federal University of São Carlos (2000-2004). She completed a doctoral degree (2002) at the Department of Microbiology, University of Virginia Health System, Charlottesville, VA, USA and postdoctoral degree (2005-2006) at the Institute de la Santé et de la Recherche Médicale (INSERM, Unité 553) in Paris, France. She was awarded a Visiting Fellowship (2015) by the University of Nottingham, England. She is currently Associate Professor at the Federal University of São Carlos. Coordinates LABEN - Laboratory of Aging Biology - located in the Department of Gerontology of UFSCar. Leads the research group Biology of Aging registered in the directory of research groups of CNPq. She is a CNPq Productivity Grant 2. She teaches in the postgraduate program in Gerontology (PPGGERO / UFSCar), where she is currently the coordinator and in the Masters and PhD courses of the Interinstitutional Program of Post-Graduation in Physiological Sciences (UFSCar / UNESP). She has experience in the field of Cell Biology and Biochemistry, with emphasis in Molecular Biology, working mainly in the following subjects: aging, elderly, biomarkers for Alzheimer's disease, cognitive fragility, ADAMs, cancer and mammalian cell culture
My main lines of research in CIBFar are: Develop classic, dynamic and functional studies related to Natural Products Chemistry in the search for bioactive substances and contribute to the understanding of the mechanisms of biosynthesis of the same ones in order to support the availability (increased production) of the same ones, in vitro biological evaluation and in vivo by omics techniques, including metabolic engineering.
My main lines of research in CIBFar are: Use of different experimental strategies for for chemical study of microbial natural products produced by endophytic microorganisms associated with the insects and metagenomic. Biological and ecological studies and pharmacological application (antibiotics, antiparasitic and anti carcinogens) of natural products.
Graduated in Biological Sciences - Bachelor's Degree and the Federal University of São Carlos (1988), Master in Ecology and Natural Resources, Federal University of São Carlos (1993) and Ph.D. in Sciences from the Federal University of São Carlos (2000). She did a Ph.D. sandwich at the Center for Biofilm Engineering (CBE, Montana State University, 1997). She is currently Professor Dr. MS-3 of Institute of Physics of São Carlos, University of São Paulo. Her research interests are: Environmental and Industrial Microbiology and 2) Science Teaching.
My main lines of research in CIBFar are: Study of natural products of vegetal origin. New bioactive molecules are investigated in plant extracts derived from the flora of the Cerrado and Atlantic Forest. Through study guided for activity it is intended to isolate substances with antiparasitic activity, anti-tumor and inhibition of various enzymes.
My main lines of research in CIBFar are: Integration computational and experimental methods used in structural biology and medicinal chemistry for the development of drugs and agrochemicals.
My main lines of research in CIBFar are: Science of the natural products: isolation, biological activity and secondary metabolites function and plant peptides; metabolomics and medicinal chemistry of natural products.