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Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colletotrichum crassipes and Xylaria sp., and Their Antifungal, Antioxidant and Anticholinesterase Activities

Authors:

Chapla, Vanessa M. 1,2 ;  Zeraik, Maria L. 1,3 ;  Cafeu, Mariana C. 1 ;  Silva, Geraldo H. 4 ; Cavalheiro, Alberto J. 1 ; Bolzani, Vanderlan S. ;  Young, Maria C. M. 5 ;  Pfenning, Ludwig H. 6 ; Araujo, Angela R. 1


Abstract:

One new natural product, 1-phenylethyl-O-alpha-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia sylvestris. Cyclo(D)-Pro-(D)-Phe, N-(2-phenylethyl) acetamide and 5-carboxy-6-hydroxy-3-methyl-3,4-dihydroisocoumarin exhibited potent antifungal activity against Cladosporium cladosporioides and C. sphaerospermum. The compounds cyclo(D)-Pro-(D)-Phe, griseofulvin, cytochalasin B and cytochalasin D exhibited antioxidant activity, and the compounds cyclo(D)-Pro-(D)-Phe, cytochalasin B and cytochalasin C showed potent acetylcholinesterase (AChE) inhibition. In addition, this is the first report on the isolation of secondary metabolites from two endophytic fungal strains, associated with Casearia sylvestris.


1  Núcleo de Bioensaios, Biossíntese & Ecofisiologia de Produtos Naturais, Instituto de Química, Universidade Estadual Paulista – UNESP,14800-900 Araraquara, SP, Brazil

2  Curso de Química Ambiental, Universidade Federal de Tocantins – UFT, 77402-970  Gurupi, TO, Brazil

3  Laboratório de Fitoquímica & Biomoléculas – LabFitoBio, Departamento de Química, Universidade Estadual de Londrina, 86051990  Londrina, PR, Brazil

4  Instituto de Ciências Exatas e Tecnológicas, Universidade Federal de Viçosa, 38810-000  Rio Paranaíba, MG, Brazil

5  Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, 01061-970 São Paulo-SP, Brazil

6  Departamento de Fitopatologia, Universidade Federal de Lavras, 37200-000 Lavras-MG, Brazil


Link para o artigo completo: http://jbcs.sbq.org.br/imagebank/pdf/2017-0416AR.pdf