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Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry

Authors:

Santos , Vânia A. F. F. M. [1] ; Dias, Nathalia B. [2] ; Teixeira,  Simone P. [3]  ; Palma , Mario S. [4] ; Furlan,  Maysa [1]

 

Abstract:

Maytenus ilicifolia (Celastraceae) is a medicinal plant that is native to southern Brazil and is popularly known as “espinheira-santa”. From a biosynthesis perspective, this species accumulates quinonemethide triterpenes and sesquiterpene pyridine alkaloids as major secondary metabolites that exhibit interesting biological properties, with antitumoral and antiprotozoal activities, respectively, being the most frequently reported. Additionally, the restricted accumulation of such compounds in the roots raises questions about the expression of proteins involved in such compartmentalization and their possible biological and/or ecological role in M. ilicifolia. Thus, this article describes the use of shotgun proteomics and histochemical studies for the characterization of the main biosynthetic pathways involved in the regulation of the metabolism in M. ilicifolia roots. This combined approaches also resulted in the identification of a series of proteins involved in the quinonemethide triterpenes and sesquiterpene pyridine alkaloids, providing evidences of their differential compartmentalization.

 

1   Instituto de Química, Universidade Estadual Paulista (Unesp), 14800-060 Araraquara-SP, Brazil

2   Scientific and Technological Bioresource Nucleus BIOREN-UFRO, Universidad de La Frontera (UFRO), 4811-230 Temuco, Chile

3   Laboratório de Botânica, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), 14040-903 Ribeirão Preto-SP, Brazil

4   Departamento de Biologia Geral e Aplicada, Instituto de Biociências, Universidade Estadual Paulista (Unesp), 13506-900 Rio Claro-SP, Brazil

 

Link to article:   https://www.scielo.br/scielo.php?pid=S0103-50532021000200237&script=sci_arttext