Authors:
Biasetto, Carolina R. [1] ; Somensi, Andressa [1] ; Sordi, Renata [1] ; Chapla, Vanessa M. [2] ; Ebrahimi, Samad N. [3] ; Silva, Geraldo H. [4] ; Teles, Helder L. [5] ; Bolzani, Vanderlan da S. [1] ; Young, Maria Claudia M. [6] ; Pfenning, Ludwig H. [7] ; Araujo, Angela R. [1]
Abstract:
Two new polyketides, named koninginin T (1) and U (2), were isolated from Phomopsis stipata – an endophytic fungus isolated from Styrax camporum Pohl. The structures of polyketides 1 and 2 were defined through the analysis of spectroscopic data. Antifungal and acetylcholinesterase inhibitory activities of these compounds were evaluated using TLC bioautographic assays. Compounds 1 and 2 displayed moderate antifungal activity and compound 1 showed acetylcholinesterase inhibitory activity.
1 Organic Chemistry Department, São Paulo State University, UNESP, Chemistry Institute, Araraquara, SP, 14800-060, Brazil
2 Environmental Chemistry, Federal University of Tocantins, UFT, Gurupi, TO, 77402-970, Brazil
3 Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, 1983963113, Iran
4 Institute of Technological and Exact Sciences, Federal University of Viçosa, Rio Paranaíba, MG, 38810-000, Brazil
5 Federal University of Mato Grosso, Department of Biological Sciences, Rondonópolis, MT, 78735-901, Brazil
6 Institute of Botany of São Paulo, São Paulo, SP, 04301-012, Brazil
7 Phytopathology Department, Federal University of Lavras, Lavras, MG, 37200-000, Brazil
Link to article: https://www.sciencedirect.com/science/article/abs/pii/S1874390019304987?via%3Dihub
