Chiral N,NLigands Enabling Palladium-Catalyzed Enantioselective Intramolecular Heck-Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions

Authors:

Carmona, Rafaela C. ¹ ;  Koster, Otto D. ¹ ;  Duarte Correia, Carlos Roque ¹

---

Abstract:

Unprecedented enantioselective intramolecular Heck carbonylation reactions of arenediazonium salts were enabled by a chiral N,Nligand. This reaction constitutes the first enantioselective Heck carbonylation that proceeds through migratory insertion followed by CO insertion. The enantioenriched functionalized dihydrobenzofurans were obtained in good to high yields and enantiomeric ratios of up to 98:2 under mild and operationally simple reaction conditions.

---

¹  University of  Campinas – UNICAMP, Chemistry Institute, BR-10384612 Sao Paulo, Brazil

---

Link to full article:  https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201805831