Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds


Dametto, Alessandra C. 1,2 ; Boralle, Nivaldo 1 ;  Zhang, Chuan-Rui 2,3 ;  Silva, Dulce H. S. 1 ;  Nair, Muraleedharan G. 2


Tea prepared from leaves of Eugenia brasiliensis has been used as a folk medicine in Brazil to alleviate inflammation and pain. In this study, tea and methanolic extract inhibited cyclooxygenase (COX-1 and -2) enzymes and lipid peroxidation (LPO). Therefore, bioassay-guided purification of methanolic extract was carried out and afforded a new lignan (aR,8S,8’R-7,8,7′,8′-tetrahydro-8,8′-dimethyl-3,3′-dimethoxy-4,4′-dihydroxy-dibenzocyclooctadiene) and three known C-methylated flavonoids (stropopinin; demethoxymatteucinol; myrigalone G). All isolates at 37.5 mu g/mL inhibited COX enzymes, similar to aspirin and ibuprofen used as controls at 108 and 12 mu g/mL, respectively. Most of the isolates also showed strong LPO inhibition at 5 mu g/mL.

1   Syaye University of São Paulo – UNESP, NuBBE Nucleus Bioassays Biosynth & Ecophysiol Nat, Inst Chem, Dept Organ Chem, BR-14800060 Araraquara, SP, Brazil

  Michigan State University, Dept Hort, Bioact Nat Prod & Phytoceut Lab, E Lansing, MI 48824 USA

  Chongqing University, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China


Volume: 13 Edition: 8 Pages: 977-980

Posted: AUG 2018