Date: May 26
Time: 10:30 am
Local: auditorium “Professor Sérgio Mascarenhas”
Speaker: Glaucius Oliva (IFSC / USP)
The main objective of this project is to know with atomic detail the structure of all Zika Virus proteins, and based on this information search for binders and antibodies that may be useful for the development of candidates for antiviral drugs and / or specific diagnoses for ZIKV. Structural-based Molecular Planning, particularly in the discovery of new bioactive compounds (drugs, biopharmaceuticals, antibodies, vaccines) is today the most efficient and cost-effective technology for the development of new drugs and can contribute to all steps of the process from the discovery of starting compounds, their optimization (affinity, specificity, efficacy, side effects) and approval by the competent organisms. In this seminar we will review the mechanisms of infection and its molecular components, especially the recent elucidation in our laboratory of the structure of the domain RNA polymerase RNA-dependent of the NS5 protein of Zika virus and the perspectives of developing compounds with potential antiviral activity for therapy and prophylaxis of the disease.
From website of São Carlos Institute of Physics of University of São Paulo: