Research ALL DrugsBiodiversity Drugs On the role of surrounding regions in the fusion peptide in dengue virus infection Drugs Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors Biodiversity, Drugs A Comprehensive LC-DAD-QTOF-MS Method for Dereplication of Bioactive Compounds in Senna Extracts Drugs Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects Drugs 3-aryl-indolinones derivatives as antiplasmodial agents: synthesis, biological activity and computational analysis Biodiversity, Drugs Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds Biodiversity Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes Drugs USY-zeolite catalyzed synthesis of 1,4-dihydropyridines under microwave irradiation: structure and recycling of the catalyst Drugs 2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling Biodiversity Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes Biodiversity, Drugs In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol Drugs Synthetic cyclopenta [b] indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells Biodiversity, Drugs Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311 Biodiversity Liquid Fungal Cocultivation as a Strategy to Access Bioactive Metabolites Drugs A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells Biodiversity Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors Biodiversity Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry Biodiversity The palladium-catalyzed Heck arylation of olefins with arenediazonium salts as a sustainable strategy in organic synthesis Biodiversity The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control Biodiversity Can Statistical Evaluation Tools for Chromatographic Method Development Assist in the Natural Products Workflow? A Case Study on Selected Species of the Plant Family Malpighiaceae Drugs Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents Drugs Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier Biodiversity Acetylcholinesterase inhibition and antifungal activity of cyclohexanoids from the endophytic fungus Saccharicola sp Drugs Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids Drugs Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment Biodiversity, Drugs Three-dimensional cell culture models for metallodrug testing: induction of apoptosis and phenotypic reversion of breast cancer cells by the trans-[Ru(PPh3)(2)(N,N-dimethyl-N-thiophenyl-thioureato-k(2)O,S)(bipy) ]PF6 complex Biodiversity, Drugs Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors Biodiversity, Drugs Chemical Ecology in Insect-microbe Interactions in the Neotropics Biodiversity, Drugs Thermal characterization and compounds identification of commercial Stevia rebaudiana Bertoni sweeteners and thermal degradation products at high temperatures by TG-DSC, IR and LC-MS/MS Drugs Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis Drugs Enantioselective Heck-Matsuda Reactions of Spirocyclopentenyl Hydantoins Directed by Non-Covalent Interactions: Total Synthesis of the (S,S)-VPC01091 Biodiversity Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity Biodiversity Pleurotusostreatus and Agaricus subrufescens: investigation of chemical composition and antioxidant properties of these mushrooms cultivated with different handmade and commercial supplements Drugs Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses Biodiversity Fragmentation study of clerodane diterpenes from Casearia species by tandem mass spectrometry (quadrupole time-of-flight and ion trap) Biodiversity Crotalaria spectabilis as a source of pyrrolizidine alkaloids and phenolic compounds: HPLC-MS/MS dereplication and monocrotaline quantification of seed and leaf extracts Biodiversity Rapid qualitative profiling of metabolites present in Fusarium solani, a rhizospheric fungus derived from Senna spectabilis, using GC/MS and UPLC-QTOF/MSE techniques assisted by UNIFI information system Drugs Catalyst-Free Conjugate Addition of Indolizines to In Situ-Generated Oxidized Morita-Baylis-Hillman Adducts Drugs Synthesis of 1,4,6-Tricarbonyl Compounds via Regioselective Gold(I)-Catalyzed Alkyne Hydration and Their Application in the Synthesis of alpha-Arylidene-butyrolactones Biodiversity, Drugs The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl Drugs Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus Biodiversity Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging Biodiversity, Drugs Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp Biodiversity, Drugs Antimicrobial activity of RP-1 peptide conjugate with ferrocene group Biodiversity Plant Metabolomics: Methods and Challenges Biodiversity, Drugs Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach Biodiversity, Drugs Structure-Based Virtual Screening, Molecular Dynamics and Binding Free Energy Calculations of Hit Candidates as ALK-5 Inhibitors Biodiversity, Drugs Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi Drugs Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors Drugs SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells Biodiversity Antimicrobial and Antibiofilm Activity of Lys-[Trp6]hy-a1 Combined with Ciprofloxacin Against Gram-Negative Bacteria Biodiversity, Drugs Antioxidant and Antibacterial Activity of Sulfonamides Derived from Carvacrol: A Structure-Activity Relationship Study Biodiversity, Drugs Molecular Docking and Quantum Studies of Lawsone Dimers Derivatives: New Investigation of Antioxidant Behavior and Antifungal Activity Drugs Preparation of tetrahydro-1H-xanthen-1-one and chromen-1-one derivatives via a Morita-Baylis-Hillman/oxa-Michael/elimination cascade Biodiversity Diterpenoids with inhibitory activity of nitrite production from Croton floribundus Drugs A new approach for identifying antagonism among fungi species and antifungal activity Biodiversity QSAR studies on benzothiophene derivatives as Plasmodium falciparum N‐myristoyltransferase inhibitors: Molecular insights into affinity and selectivity Biodiversity CYP712K4 Catalyzes the C-29 Oxidation of Friedelin in the Maytenus ilicifolia Quinone Methide Triterpenoid Biosynthesis Pathway Drugs Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti Drugs Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi Drugs Modeling Studies for the DisStructure-Based and Molecularcovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity Drugs Enantioselective Heck Arylation of Acyclic Alkenol Aryl Ethers: Synthetic Applications and DFT Investigation of the Stereoselectivity Drugs Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies Biodiversity Antimicrobial and antibiofilm activities of Casearia sylvestris extracts from distinct Brazilian biomes against Streptococcus mutans and Candida albicans Drugs Iron-Catalyzed Meerwein Carbooxygenation of Electron-Rich Olefins: Studies with Styrenes, Vinyl Pyrrolidinone, and Vinyl Oxazolidinone Drugs Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis Drugs Dissemination of blaKPC-2 in an NTEKPC by an IncX5 plasmid Drugs Natural deep eutectic solvents and aqueous solutions as an alternative extraction media for propolis Drugs Computational methods for NMR and MS for structure elucidation I: software for basic NMR Drugs Unveiling the binding and orientation of the antimicrobial peptide Plantaricin 149 in zwitterionic and negatively charged membranes Drugs Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots Biodiversity Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani Drugs SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells Biodiversity Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human Neonatal Foreskin Fibroblasts in vitro and Collagen Deposition Drugs Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents Biodiversity Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis – Falkenbergia stage Biodiversity PHYTOTOXIC CONSTITUENTS FROM ENDOPHYTIC FUNGUS Xylaria cubensis ASSOCIATED WITH Eugenia brasiliensis Drugs ADMET modeling approaches in drug discovery Drugs Improvement of bioactive metabolite production in microbial cultures—A systems approach by OSMAC and deconvolution‐based 1HNMR quantification Drugs In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya procera (Lem.) Traub (Amaryllidaceae) Drugs Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases Biodiversity Combined use of tandem mass spectrometry and computational chemistry to study 2H‐chromenes from Piper aduncum Drugs Organocatalytic asymmetric vinylogous 1,4-addition of α,α-Dicyanoolefins to chalcones under a bio-based reaction media: Discovery of new Michael adducts with antiplasmodial activity Drugs Quantitative Structure–Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity Biodiversity Quantitative Structure–Activity Relationships Drugs Palladium-Mediated Oxidative Annulation of δ-Indolyl-α,β-Unsaturated Compounds toward the Synthesis of Cyclopenta[b]indoles and Heterogeneous Hydrogenation To Access Fused Indolines Drugs Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis Drugs Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) Biodiversity A brief overview on Brazilian women in chemistry Drugs Recent advances in indoline synthesis Drugs Oxidative functionalization of a halimane diterpenoid achieved by fungal transformation Biodiversity Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection Biodiversity Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam Drugs Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents Biodiversity Chemical Space and Diversity of the NuBBE Database: A Chemoinformatic Characterization Biodiversity Dimerization of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity Drugs Vinyl-1,2,4-oxadiazoles Behave as Nucleophilic Partners in Morita-Baylis-Hillman Reactions Biodiversity Dimeric chalcones derivatives from Myracrodruon urundeuva act as cathepsin V inhibitors Drugs In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide Biodiversity Chemical composition and biological properties of Ipomoea procumbens Biodiversity Using natural deep eutectic solvents for the extraction of metabolites in Byrsonima intermedia leaves Biodiversity, Drugs Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes Drugs Chemoinformatics Strategies for Leishmaniasis Drug Discovery Drugs Enantioselective Synthesis of Phthalides and Isochromanones viaHeck–Matsuda Arylation of Dihydrofurans Biodiversity Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins Drugs GA-Hecate antiviral properties on HCV whole cycle represent a new antiviral class and open the door for the development of broad spectrum antivirals Drugs Heterogenous green catalysis: Application of zeolites on multicomponent reactions Biodiversity, Drugs Phthalimide Derivatives with Bioactivity against Plasmodium falciparum: Synthesis, Evaluation, and Computational Studies Involving bc1Cytochrome Inhibition Drugs Daptomycin and vancomycin heteroresistance revealed among CC5-SCCmecII MRSA clone and in vitro evaluation of treatment alternatives Biodiversity A Cyclotide Isolated from Noisettia orchidiflora (Violaceae) Biodiversity Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds Biodiversity Dissecting the mechanism of action of actinoporins. Role of the N-terminal amphipathic alpha-helix in membrane binding and pore activity of sticholysins I and II Biodiversity, Drugs Quinoxaline derivatives as potential antitrypanosomal and antileishmanial agents Drugs Enantioselective, Noncovalent, Substrate-Directable Heck-Matsuda and Oxidative Heck Arylations of Unactivated Five-Membered Carbocyclic Olefins Drugs Chiral N,NLigands Enabling Palladium-Catalyzed Enantioselective Intramolecular Heck-Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions Biodiversity, Drugs Unveiling the fungal biotransformation of hydralazine using C-13-precursor Drugs Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes Biodiversity Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colletotrichum crassipes and Xylaria sp., and Their Antifungal, Antioxidant and Anticholinesterase Activities Drugs Molecular Cloning and Biochemical Characterization of Iron Superoxide Dismutase from Leishmania braziliensis Biodiversity Stingless Bee Larvae Require Fungal Steroid to Pupate Biodiversity Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms Drugs Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface Drugs Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography—searching for alternatives to organic solvents Biodiversity A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway Biodiversity Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with In Vivo Activity Biodiversity Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria Biodiversity Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae) Biodiversity, Drugs LmrBPP9: A synthetic bradykinin-potentiating peptide from Lachesis muta rhombeata venom that inhibits the angiotensin-converting enzyme activity in vitro and reduces the blood pressure of hypertensive rats Biodiversity Thermoanalytical and spectroscopic characteristics of young and old leaves powder and methanolic extracts of Niedenzuella multiglandulosa Biodiversity Chemical signaling involved in plant–microbe interactions Biodiversity, Drugs In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide Biodiversity Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum Biodiversity, Drugs Dereplication by HPLC‐DAD‐ESI‐MS/MS and Screening for Biological Activities of Byrsonima Species (Malpighiaceae) Biodiversity, Drugs Can an Alcohol Act As an Acid/Base Catalyst in Water Solution? An Experimental and Theoretical Study of Imidazole Catalysis of the Aqueous Morita-Baylis–Hillman Reaction Biodiversity, Drugs Targeting cysteine proteases in trypanosomatid disease drug discovery Biodiversity, Drugs Amphotericin B as an inducer of griseofulvin-containing guttate in the endophytic fungus Xylaria cubensis FLe9 Biodiversity, Drugs Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer Biodiversity, Drugs Endophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae) Biodiversity Proteomic profile of Piper tuberculatum (Piperaceae) Biodiversity, Drugs Short and Diastereoselective Total Synthesis of the Polyhydroxylated Pyrrolidine LAB-1: A Potent α-Glycosidase Inhibitor Biodiversity, Drugs Asymmetric synthesis and evaluation of epoxy-α-acyloxycarboxamides as selective inhibitors of cathepsin L Biodiversity, Drugs Asymmetric synthesis of new gamma-butenolides via organocatalyzed epoxidation of chalcones Biodiversity NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity Biodiversity, Drugs Proteome profiling reveals insights into secondary metabolism in Maytenus ilicifolia (Celastraceae) cell cultures producing quinonemethide triterpenes Biodiversity, Drugs Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides Biodiversity, Drugs Pinpointing disulfide connectivities in cysteine-rich proteins Biodiversity, Drugs Impairment of the class IIa bacteriocin receptor function and membrane structural changes are associated to enterocin CRL35 high resistance in Listeria monocytogenes Biodiversity, Drugs Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation Biodiversity, Drugs Update: Biological and Chemical Aspects of Senna spectabilis Biodiversity ONE STRAIN-MANY COMPOUNDS (OSMAC) METHOD FOR PRODUCTION OF PHENOLIC COMPOUNDS USING Camarops sp., AN ENDOPHYTIC FUNGUS FROM Alibertia macrophylla (Rubiaceae) Biodiversity, Drugs Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase Biodiversity, Drugs Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration Biodiversity, Drugs Discovery of Novel Antischistosomal Agents by Molecular Modeling Approaches Biodiversity, Drugs Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene Biodiversity Vibrational spectroscopy in the study of natural products chirality Biodiversity, Drugs Microbiota of ants is a target for research on new drugs Biodiversity, Drugs Characterization and biological activity of the peptide Jatrophidin I Biodiversity, Drugs Bioactive secondary metabolites of Senna spectabilis
Biodiversity, Drugs A Comprehensive LC-DAD-QTOF-MS Method for Dereplication of Bioactive Compounds in Senna Extracts
Drugs Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects
Drugs 3-aryl-indolinones derivatives as antiplasmodial agents: synthesis, biological activity and computational analysis
Biodiversity, Drugs Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
Biodiversity Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes
Drugs USY-zeolite catalyzed synthesis of 1,4-dihydropyridines under microwave irradiation: structure and recycling of the catalyst
Biodiversity, Drugs In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol
Drugs Synthetic cyclopenta [b] indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells
Drugs A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells
Biodiversity Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors
Biodiversity Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry
Biodiversity The palladium-catalyzed Heck arylation of olefins with arenediazonium salts as a sustainable strategy in organic synthesis
Biodiversity The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control
Biodiversity Can Statistical Evaluation Tools for Chromatographic Method Development Assist in the Natural Products Workflow? A Case Study on Selected Species of the Plant Family Malpighiaceae
Drugs Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier
Biodiversity Acetylcholinesterase inhibition and antifungal activity of cyclohexanoids from the endophytic fungus Saccharicola sp
Drugs Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids
Drugs Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment
Biodiversity, Drugs Three-dimensional cell culture models for metallodrug testing: induction of apoptosis and phenotypic reversion of breast cancer cells by the trans-[Ru(PPh3)(2)(N,N-dimethyl-N-thiophenyl-thioureato-k(2)O,S)(bipy) ]PF6 complex
Biodiversity, Drugs Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors
Biodiversity, Drugs Thermal characterization and compounds identification of commercial Stevia rebaudiana Bertoni sweeteners and thermal degradation products at high temperatures by TG-DSC, IR and LC-MS/MS
Drugs Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis
Drugs Enantioselective Heck-Matsuda Reactions of Spirocyclopentenyl Hydantoins Directed by Non-Covalent Interactions: Total Synthesis of the (S,S)-VPC01091
Biodiversity Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity
Biodiversity Pleurotusostreatus and Agaricus subrufescens: investigation of chemical composition and antioxidant properties of these mushrooms cultivated with different handmade and commercial supplements
Biodiversity Fragmentation study of clerodane diterpenes from Casearia species by tandem mass spectrometry (quadrupole time-of-flight and ion trap)
Biodiversity Crotalaria spectabilis as a source of pyrrolizidine alkaloids and phenolic compounds: HPLC-MS/MS dereplication and monocrotaline quantification of seed and leaf extracts
Biodiversity Rapid qualitative profiling of metabolites present in Fusarium solani, a rhizospheric fungus derived from Senna spectabilis, using GC/MS and UPLC-QTOF/MSE techniques assisted by UNIFI information system
Drugs Catalyst-Free Conjugate Addition of Indolizines to In Situ-Generated Oxidized Morita-Baylis-Hillman Adducts
Drugs Synthesis of 1,4,6-Tricarbonyl Compounds via Regioselective Gold(I)-Catalyzed Alkyne Hydration and Their Application in the Synthesis of alpha-Arylidene-butyrolactones
Biodiversity, Drugs The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl
Drugs Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus
Biodiversity Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging
Biodiversity, Drugs Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach
Biodiversity, Drugs Structure-Based Virtual Screening, Molecular Dynamics and Binding Free Energy Calculations of Hit Candidates as ALK-5 Inhibitors
Biodiversity, Drugs Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi
Drugs Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors
Drugs SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells
Biodiversity Antimicrobial and Antibiofilm Activity of Lys-[Trp6]hy-a1 Combined with Ciprofloxacin Against Gram-Negative Bacteria
Biodiversity, Drugs Antioxidant and Antibacterial Activity of Sulfonamides Derived from Carvacrol: A Structure-Activity Relationship Study
Biodiversity, Drugs Molecular Docking and Quantum Studies of Lawsone Dimers Derivatives: New Investigation of Antioxidant Behavior and Antifungal Activity
Drugs Preparation of tetrahydro-1H-xanthen-1-one and chromen-1-one derivatives via a Morita-Baylis-Hillman/oxa-Michael/elimination cascade
Biodiversity QSAR studies on benzothiophene derivatives as Plasmodium falciparum N‐myristoyltransferase inhibitors: Molecular insights into affinity and selectivity
Biodiversity CYP712K4 Catalyzes the C-29 Oxidation of Friedelin in the Maytenus ilicifolia Quinone Methide Triterpenoid Biosynthesis Pathway
Drugs Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti
Drugs Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi
Drugs Modeling Studies for the DisStructure-Based and Molecularcovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity
Drugs Enantioselective Heck Arylation of Acyclic Alkenol Aryl Ethers: Synthetic Applications and DFT Investigation of the Stereoselectivity
Drugs Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies
Biodiversity Antimicrobial and antibiofilm activities of Casearia sylvestris extracts from distinct Brazilian biomes against Streptococcus mutans and Candida albicans
Drugs Iron-Catalyzed Meerwein Carbooxygenation of Electron-Rich Olefins: Studies with Styrenes, Vinyl Pyrrolidinone, and Vinyl Oxazolidinone
Drugs Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis
Drugs Natural deep eutectic solvents and aqueous solutions as an alternative extraction media for propolis
Drugs Unveiling the binding and orientation of the antimicrobial peptide Plantaricin 149 in zwitterionic and negatively charged membranes
Drugs Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots
Biodiversity Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani
Drugs SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells
Biodiversity Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human Neonatal Foreskin Fibroblasts in vitro and Collagen Deposition
Drugs Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents
Biodiversity Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis – Falkenbergia stage
Biodiversity PHYTOTOXIC CONSTITUENTS FROM ENDOPHYTIC FUNGUS Xylaria cubensis ASSOCIATED WITH Eugenia brasiliensis
Drugs Improvement of bioactive metabolite production in microbial cultures—A systems approach by OSMAC and deconvolution‐based 1HNMR quantification
Drugs In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya procera (Lem.) Traub (Amaryllidaceae)
Drugs Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases
Biodiversity Combined use of tandem mass spectrometry and computational chemistry to study 2H‐chromenes from Piper aduncum
Drugs Organocatalytic asymmetric vinylogous 1,4-addition of α,α-Dicyanoolefins to chalcones under a bio-based reaction media: Discovery of new Michael adducts with antiplasmodial activity
Drugs Quantitative Structure–Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity
Drugs Palladium-Mediated Oxidative Annulation of δ-Indolyl-α,β-Unsaturated Compounds toward the Synthesis of Cyclopenta[b]indoles and Heterogeneous Hydrogenation To Access Fused Indolines
Drugs Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis
Drugs Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)
Biodiversity Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection
Biodiversity Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam
Drugs Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents
Biodiversity Dimerization of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity
Drugs In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide
Biodiversity Using natural deep eutectic solvents for the extraction of metabolites in Byrsonima intermedia leaves
Drugs Enantioselective Synthesis of Phthalides and Isochromanones viaHeck–Matsuda Arylation of Dihydrofurans
Biodiversity Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins
Drugs GA-Hecate antiviral properties on HCV whole cycle represent a new antiviral class and open the door for the development of broad spectrum antivirals
Biodiversity, Drugs Phthalimide Derivatives with Bioactivity against Plasmodium falciparum: Synthesis, Evaluation, and Computational Studies Involving bc1Cytochrome Inhibition
Drugs Daptomycin and vancomycin heteroresistance revealed among CC5-SCCmecII MRSA clone and in vitro evaluation of treatment alternatives
Biodiversity Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds
Biodiversity Dissecting the mechanism of action of actinoporins. Role of the N-terminal amphipathic alpha-helix in membrane binding and pore activity of sticholysins I and II
Drugs Enantioselective, Noncovalent, Substrate-Directable Heck-Matsuda and Oxidative Heck Arylations of Unactivated Five-Membered Carbocyclic Olefins
Drugs Chiral N,NLigands Enabling Palladium-Catalyzed Enantioselective Intramolecular Heck-Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions
Drugs Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes
Biodiversity Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colletotrichum crassipes and Xylaria sp., and Their Antifungal, Antioxidant and Anticholinesterase Activities
Drugs Molecular Cloning and Biochemical Characterization of Iron Superoxide Dismutase from Leishmania braziliensis
Drugs Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography—searching for alternatives to organic solvents
Biodiversity A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway
Biodiversity Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with In Vivo Activity
Biodiversity Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria
Biodiversity Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae)
Biodiversity, Drugs LmrBPP9: A synthetic bradykinin-potentiating peptide from Lachesis muta rhombeata venom that inhibits the angiotensin-converting enzyme activity in vitro and reduces the blood pressure of hypertensive rats
Biodiversity Thermoanalytical and spectroscopic characteristics of young and old leaves powder and methanolic extracts of Niedenzuella multiglandulosa
Biodiversity, Drugs In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide
Biodiversity Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum
Biodiversity, Drugs Dereplication by HPLC‐DAD‐ESI‐MS/MS and Screening for Biological Activities of Byrsonima Species (Malpighiaceae)
Biodiversity, Drugs Can an Alcohol Act As an Acid/Base Catalyst in Water Solution? An Experimental and Theoretical Study of Imidazole Catalysis of the Aqueous Morita-Baylis–Hillman Reaction
Biodiversity, Drugs Amphotericin B as an inducer of griseofulvin-containing guttate in the endophytic fungus Xylaria cubensis FLe9
Biodiversity, Drugs Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer
Biodiversity, Drugs Endophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae)
Biodiversity, Drugs Short and Diastereoselective Total Synthesis of the Polyhydroxylated Pyrrolidine LAB-1: A Potent α-Glycosidase Inhibitor
Biodiversity, Drugs Asymmetric synthesis and evaluation of epoxy-α-acyloxycarboxamides as selective inhibitors of cathepsin L
Biodiversity, Drugs Asymmetric synthesis of new gamma-butenolides via organocatalyzed epoxidation of chalcones
Biodiversity NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
Biodiversity, Drugs Proteome profiling reveals insights into secondary metabolism in Maytenus ilicifolia (Celastraceae) cell cultures producing quinonemethide triterpenes
Biodiversity, Drugs Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides
Biodiversity, Drugs Impairment of the class IIa bacteriocin receptor function and membrane structural changes are associated to enterocin CRL35 high resistance in Listeria monocytogenes
Biodiversity, Drugs Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation
Biodiversity ONE STRAIN-MANY COMPOUNDS (OSMAC) METHOD FOR PRODUCTION OF PHENOLIC COMPOUNDS USING Camarops sp., AN ENDOPHYTIC FUNGUS FROM Alibertia macrophylla (Rubiaceae)
Biodiversity, Drugs Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration
Biodiversity, Drugs Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene
