Pesquisa Todas FármacosBiodiversidade Fármacos On the role of surrounding regions in the fusion peptide in dengue virus infection Fármacos Chemoinformatics Studies on a Series of Imidazoles as Cruzain Inhibitors Biodiversidade, Fármacos A Comprehensive LC-DAD-QTOF-MS Method for Dereplication of Bioactive Compounds in Senna Extracts Fármacos Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects Fármacos 3-aryl-indolinones derivatives as antiplasmodial agents: synthesis, biological activity and computational analysis Biodiversidade, Fármacos Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds Biodiversidade Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes Fármacos USY-zeolite catalyzed synthesis of 1,4-dihydropyridines under microwave irradiation: structure and recycling of the catalyst Fármacos 2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling Biodiversidade Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes Biodiversidade, Fármacos In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol Fármacos Synthetic cyclopenta [b] indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells Biodiversidade, Fármacos Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311 Biodiversidade Liquid Fungal Cocultivation as a Strategy to Access Bioactive Metabolites Fármacos A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells Biodiversidade Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors Biodiversidade Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry Biodiversidade, Fármacos In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol Biodiversidade The palladium-catalyzed Heck arylation of olefins with arenediazonium salts as a sustainable strategy in organic synthesis Biodiversidade The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control Biodiversidade Can Statistical Evaluation Tools for Chromatographic Method Development Assist in the Natural Products Workflow? A Case Study on Selected Species of the Plant Family Malpighiaceae Fármacos Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents Fármacos Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier Biodiversidade Acetylcholinesterase inhibition and antifungal activity of cyclohexanoids from the endophytic fungus Saccharicola sp Fármacos Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids Fármacos Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment Biodiversidade, Fármacos Three-dimensional cell culture models for metallodrug testing: induction of apoptosis and phenotypic reversion of breast cancer cells by the trans-[Ru(PPh3)(2)(N,N-dimethyl-N-thiophenyl-thioureato-k(2)O,S)(bipy) ]PF6 complex Biodiversidade, Fármacos Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors Biodiversidade Chemical Ecology in Insect-microbe Interactions in the Neotropics Biodiversidade, Fármacos Thermal characterization and compounds identification of commercial Stevia rebaudiana Bertoni sweeteners and thermal degradation products at high temperatures by TG-DSC, IR and LC-MS/MS Fármacos Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis Fármacos Enantioselective Heck-Matsuda Reactions of Spirocyclopentenyl Hydantoins Directed by Non-Covalent Interactions: Total Synthesis of the (S,S)-VPC01091 Biodiversidade Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity Biodiversidade Pleurotusostreatus and Agaricus subrufescens: investigation of chemical composition and antioxidant properties of these mushrooms cultivated with different handmade and commercial supplements Fármacos Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses Biodiversidade Fragmentation study of clerodane diterpenes from Casearia species by tandem mass spectrometry (quadrupole time-of-flight and ion trap) Biodiversidade Crotalaria spectabilis as a source of pyrrolizidine alkaloids and phenolic compounds: HPLC-MS/MS dereplication and monocrotaline quantification of seed and leaf extracts Biodiversidade Rapid qualitative profiling of metabolites present in Fusarium solani, a rhizospheric fungus derived from Senna spectabilis, using GC/MS and UPLC-QTOF/MSE techniques assisted by UNIFI information system Fármacos Catalyst-Free Conjugate Addition of Indolizines to In Situ-Generated Oxidized Morita-Baylis-Hillman Adducts Fármacos Synthesis of 1,4,6-Tricarbonyl Compounds via Regioselective Gold(I)-Catalyzed Alkyne Hydration and Their Application in the Synthesis of alpha-Arylidene-butyrolactones Biodiversidade, Fármacos The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl Fármacos Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus Biodiversidade Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging Biodiversidade, Fármacos Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp Biodiversidade, Fármacos Antimicrobial activity of RP-1 peptide conjugate with ferrocene group Biodiversidade Metabolômica de Plantas: Métodos e Desafios Biodiversidade, Fármacos Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach Biodiversidade, Fármacos Structure-Based Virtual Screening, Molecular Dynamics and Binding Free Energy Calculations of Hit Candidates as ALK-5 Inhibitors Biodiversidade, Fármacos Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi Fármacos Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors Fármacos SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells Biodiversidade, Fármacos Antimicrobial and Antibiofilm Activity of Lys-[Trp6]hy-a1 Combined with Ciprofloxacin Against Gram-Negative Bacteria Biodiversidade, Fármacos Antioxidant and Antibacterial Activity of Sulfonamides Derived from Carvacrol: A Structure-Activity Relationship Study Biodiversidade, Fármacos Molecular Docking and Quantum Studies of Lawsone Dimers Derivatives: New Investigation of Antioxidant Behavior and Antifungal Activity Fármacos Preparation of tetrahydro-1H-xanthen-1-one and chromen-1-one derivatives via a Morita-Baylis-Hillman/oxa-Michael/elimination cascade Biodiversidade Diterpenoids with inhibitory activity of nitrite production from Croton floribundus Fármacos A new approach for identifying antagonism among fungi species and antifungal activity Biodiversidade QSAR studies on benzothiophene derivatives as Plasmodium falciparum N‐myristoyltransferase inhibitors: Molecular insights into affinity and selectivity Biodiversidade CYP712K4 Catalyzes the C-29 Oxidation of Friedelin in the Maytenus ilicifolia Quinone Methide Triterpenoid Biosynthesis Pathway Fármacos Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti Fármacos Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi Fármacos Modeling Studies for the DisStructure-Based and Molecularcovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity Fármacos Enantioselective Heck Arylation of Acyclic Alkenol Aryl Ethers: Synthetic Applications and DFT Investigation of the Stereoselectivity Fármacos Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies Biodiversidade Antimicrobial and antibiofilm activities of Casearia sylvestris extracts from distinct Brazilian biomes against Streptococcus mutans and Candida albicans Fármacos Iron-Catalyzed Meerwein Carbooxygenation of Electron-Rich Olefins: Studies with Styrenes, Vinyl Pyrrolidinone, and Vinyl Oxazolidinone Fármacos Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis Fármacos Computational methods for NMR and MS for structure elucidation II: database resources and advanced methods Fármacos Dissemination of blaKPC-2 in an NTEKPC by an IncX5 plasmid Fármacos Natural deep eutectic solvents and aqueous solutions as an alternative extraction media for propolis Fármacos Computational methods for NMR and MS for structure elucidation I: software for basic NMR Fármacos Unveiling the binding and orientation of the antimicrobial peptide Plantaricin 149 in zwitterionic and negatively charged membranes Fármacos Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots Biodiversidade Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani Fármacos SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells Biodiversidade Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human Neonatal Foreskin Fibroblasts in vitro and Collagen Deposition Fármacos Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents Biodiversidade Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis – Falkenbergia stage Biodiversidade PHYTOTOXIC CONSTITUENTS FROM ENDOPHYTIC FUNGUS Xylaria cubensis ASSOCIATED WITH Eugenia brasiliensis Fármacos ADMET modeling approaches in drug discovery Fármacos Improvement of bioactive metabolite production in microbial cultures—A systems approach by OSMAC and deconvolution‐based 1HNMR quantification Fármacos In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya procera (Lem.) Traub (Amaryllidaceae) Fármacos Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases Biodiversidade Combined use of tandem mass spectrometry and computational chemistry to study 2H‐chromenes from Piper aduncum Fármacos Organocatalytic asymmetric vinylogous 1,4-addition of α,α-Dicyanoolefins to chalcones under a bio-based reaction media: Discovery of new Michael adducts with antiplasmodial activity Fármacos Quantitative Structure–Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity Biodiversidade Quantitative Structure–Activity Relationships Fármacos Palladium-Mediated Oxidative Annulation of δ-Indolyl-α,β-Unsaturated Compounds toward the Synthesis of Cyclopenta[b]indoles and Heterogeneous Hydrogenation To Access Fused Indolines Fármacos Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis Fármacos Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) Biodiversidade A brief overview on Brazilian women in chemistry Fármacos Recent advances in indoline synthesis Fármacos Oxidative functionalization of a halimane diterpenoid achieved by fungal transformation Biodiversidade Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection Biodiversidade Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam Fármacos Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents Biodiversidade Chemical Space and Diversity of the NuBBE Database: A Chemoinformatic Characterization Biodiversidade Dimerization of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity Fármacos Vinyl-1,2,4-oxadiazoles Behave as Nucleophilic Partners in Morita-Baylis-Hillman Reactions Biodiversidade Dimeric chalcones derivatives from Myracrodruon urundeuva act as cathepsin V inhibitors Fármacos In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide Biodiversidade Chemical composition and biological properties of Ipomoea procumbens Biodiversidade Using natural deep eutectic solvents for the extraction of metabolites in Byrsonima intermedia leaves Biodiversidade, Fármacos Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes Fármacos Chemoinformatics Strategies for Leishmaniasis Drug Discovery Fármacos Enantioselective Synthesis of Phthalides and Isochromanones viaHeck–Matsuda Arylation of Dihydrofurans Biodiversidade Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins Fármacos GA-Hecate antiviral properties on HCV whole cycle represent a new antiviral class and open the door for the development of broad spectrum antivirals Fármacos Heterogenous green catalysis: Application of zeolites on multicomponent reactions Biodiversidade, Fármacos Phthalimide Derivatives with Bioactivity against Plasmodium falciparum: Synthesis, Evaluation, and Computational Studies Involving bc1Cytochrome Inhibition Fármacos Daptomycin and vancomycin heteroresistance revealed among CC5-SCCmecII MRSA clone and in vitro evaluation of treatment alternatives Biodiversidade A Cyclotide Isolated from Noisettia orchidiflora (Violaceae) Biodiversidade Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds Biodiversidade Dissecting the mechanism of action of actinoporins. Role of the N-terminal amphipathic alpha-helix in membrane binding and pore activity of sticholysins I and II Biodiversidade, Fármacos Quinoxaline derivatives as potential antitrypanosomal and antileishmanial agents Fármacos Enantioselective, Noncovalent, Substrate-Directable Heck-Matsuda and Oxidative Heck Arylations of Unactivated Five-Membered Carbocyclic Olefins Fármacos Chiral N,NLigands Enabling Palladium-Catalyzed Enantioselective Intramolecular Heck-Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions Biodiversidade, Fármacos Unveiling the fungal biotransformation of hydralazine using C-13-precursor Fármacos Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes Biodiversidade Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colletotrichum crassipes and Xylaria sp., and Their Antifungal, Antioxidant and Anticholinesterase Activities Fármacos Molecular Cloning and Biochemical Characterization of Iron Superoxide Dismutase from Leishmania braziliensis Biodiversidade Stingless Bee Larvae Require Fungal Steroid to Pupate Biodiversidade Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms Fármacos Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface Fármacos Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography—searching for alternatives to organic solvents Biodiversidade A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway Biodiversidade Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with In Vivo Activity Biodiversidade Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria Biodiversidade Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae) Biodiversidade, Fármacos LmrBPP9: A synthetic bradykinin-potentiating peptide from Lachesis muta rhombeata venom that inhibits the angiotensin-converting enzyme activity in vitro and reduces the blood pressure of hypertensive rats Biodiversidade Thermoanalytical and spectroscopic characteristics of young and old leaves powder and methanolic extracts of Niedenzuella multiglandulosa Biodiversidade Chemical signaling involved in plant–microbe interactions Biodiversidade, Fármacos In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide Biodiversidade Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum Biodiversidade, Fármacos Dereplication by HPLC‐DAD‐ESI‐MS/MS and Screening for Biological Activities of Byrsonima Species (Malpighiaceae) Biodiversidade, Fármacos Can an Alcohol Act As an Acid/Base Catalyst in Water Solution? An Experimental and Theoretical Study of Imidazole Catalysis of the Aqueous Morita-Baylis–Hillman Reaction Biodiversidade, Fármacos Targeting cysteine proteases in trypanosomatid disease drug discovery Biodiversidade, Fármacos Amphotericin B as an inducer of griseofulvin-containing guttate in the endophytic fungus Xylaria cubensis FLe9 Biodiversidade, Fármacos Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer Biodiversidade, Fármacos Endophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae) Biodiversidade Proteomic profile of Piper tuberculatum (Piperaceae) Biodiversidade, Fármacos Short and Diastereoselective Total Synthesis of the Polyhydroxylated Pyrrolidine LAB-1: A Potent α-Glycosidase Inhibitor Biodiversidade, Fármacos Asymmetric synthesis and evaluation of epoxy-α-acyloxycarboxamides as selective inhibitors of cathepsin L Biodiversidade, Fármacos Asymmetric synthesis of new gamma-butenolides via organocatalyzed epoxidation of chalcones Biodiversidade NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity Biodiversidade, Fármacos Proteome profiling reveals insights into secondary metabolism in Maytenus ilicifolia (Celastraceae) cell cultures producing quinonemethide triterpenes Biodiversidade, Fármacos Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides Biodiversidade, Fármacos Pinpointing disulfide connectivities in cysteine-rich proteins Biodiversidade, Fármacos Impairment of the class IIa bacteriocin receptor function and membrane structural changes are associated to enterocin CRL35 high resistance in Listeria monocytogenes Biodiversidade, Fármacos Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation Biodiversidade, Fármacos Update: Biological and Chemical Aspects of Senna spectabilis Biodiversidade ONE STRAIN-MANY COMPOUNDS (OSMAC) METHOD FOR PRODUCTION OF PHENOLIC COMPOUNDS USING Camarops sp., AN ENDOPHYTIC FUNGUS FROM Alibertia macrophylla (Rubiaceae) Biodiversidade, Fármacos Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase Biodiversidade, Fármacos Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration Biodiversidade, Fármacos Discovery of Novel Antischistosomal Agents by Molecular Modeling Approaches Biodiversidade, Fármacos Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene Biodiversidade, Fármacos Espectroscopia vibracional no estudo da quiralidade de produtos naturais Biodiversidade, Fármacos Caracterização e atividade biológica do peptídeo Jatrophidin I Biodiversidade, Fármacos Metabólitos secundários bioativos da Senna spectabilis Biodiversidade, Fármacos Microbiota de formigas é alvo para pesquisa de novos fármacos Biodiversidade, Fármacos Alterações conformacionais induzidas por DMSO Biodiversidade, Fármacos Propriedades anticolinesterásicas da Tetrapterys mucronata Biodiversidade, Fármacos Novos compostos com atividade tripanocida Biodiversidade, Fármacos Novos compostos ativos contra a arginase de L. amazonensis Biodiversidade, Fármacos Dimerização altera a atividade de peptídeos antimicrobianos Biodiversidade, Fármacos Quinoxalina 4: uma nova molécula contra o Trypanosoma cruzi Biodiversidade, Fármacos Utilização de culturas mistas na produção de metabólitos ativos Biodiversidade, Fármacos Parceria entre USP e UNESP produz a primeira base de dados de produtos naturais do Brasil Biodiversidade, Fármacos Inibidores da tripanotiona redutase são alvo de estudo do CIBFar Biodiversidade, Fármacos Novos compostos com potencial anti-chagásico
Biodiversidade, Fármacos A Comprehensive LC-DAD-QTOF-MS Method for Dereplication of Bioactive Compounds in Senna Extracts
Fármacos Discovery of a Novel Lineage Burkholderia cepacia ST 1870 Endophytically Isolated from Medicinal Polygala paniculata Which Shows Potent In Vitro Antileishmanial and Antimicrobial Effects
Fármacos 3-aryl-indolinones derivatives as antiplasmodial agents: synthesis, biological activity and computational analysis
Biodiversidade, Fármacos Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds
Biodiversidade Infraspecific Chemical Variability and Biological Activity of Casearia sylvestris from Different Brazilian Biomes
Fármacos USY-zeolite catalyzed synthesis of 1,4-dihydropyridines under microwave irradiation: structure and recycling of the catalyst
Biodiversidade, Fármacos In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol
Fármacos Synthetic cyclopenta [b] indoles exhibit antineoplastic activity by targeting microtubule dynamics in acute myeloid leukemia cells
Fármacos A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells
Biodiversidade Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors
Biodiversidade Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Integrated Proteomics and Histochemistry
Biodiversidade, Fármacos In vitro bioassay guided anti-dermatophyte and cytotoxic activities from Piper umbellatum L. Miq. led to 4-nerolidylcatechol
Biodiversidade The palladium-catalyzed Heck arylation of olefins with arenediazonium salts as a sustainable strategy in organic synthesis
Biodiversidade The Potential of Biologically Active Brazilian Plant Species as a Strategy to Search for Molecular Models for Mosquito Control
Biodiversidade Can Statistical Evaluation Tools for Chromatographic Method Development Assist in the Natural Products Workflow? A Case Study on Selected Species of the Plant Family Malpighiaceae
Fármacos Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents
Fármacos Insights on the Quest for the Structure-Function Relationship of the Mitochondrial Pyruvate Carrier
Biodiversidade Acetylcholinesterase inhibition and antifungal activity of cyclohexanoids from the endophytic fungus Saccharicola sp
Fármacos Discovery of highly potent and selective antiparasitic new oxadiazole and hydroxy-oxindole small molecule hybrids
Fármacos Copper transporter 1 affinity as a delivery strategy to improve the cytotoxic profile of rationally designed copper(II) complexes for cancer treatment
Biodiversidade, Fármacos Three-dimensional cell culture models for metallodrug testing: induction of apoptosis and phenotypic reversion of breast cancer cells by the trans-[Ru(PPh3)(2)(N,N-dimethyl-N-thiophenyl-thioureato-k(2)O,S)(bipy) ]PF6 complex
Biodiversidade, Fármacos Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors
Biodiversidade, Fármacos Thermal characterization and compounds identification of commercial Stevia rebaudiana Bertoni sweeteners and thermal degradation products at high temperatures by TG-DSC, IR and LC-MS/MS
Fármacos Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis
Fármacos Enantioselective Heck-Matsuda Reactions of Spirocyclopentenyl Hydantoins Directed by Non-Covalent Interactions: Total Synthesis of the (S,S)-VPC01091
Biodiversidade Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity
Biodiversidade Pleurotusostreatus and Agaricus subrufescens: investigation of chemical composition and antioxidant properties of these mushrooms cultivated with different handmade and commercial supplements
Fármacos Reporter Replicons for Antiviral Drug Discovery against Positive Single-Stranded RNA Viruses
Biodiversidade Fragmentation study of clerodane diterpenes from Casearia species by tandem mass spectrometry (quadrupole time-of-flight and ion trap)
Biodiversidade Crotalaria spectabilis as a source of pyrrolizidine alkaloids and phenolic compounds: HPLC-MS/MS dereplication and monocrotaline quantification of seed and leaf extracts
Biodiversidade Rapid qualitative profiling of metabolites present in Fusarium solani, a rhizospheric fungus derived from Senna spectabilis, using GC/MS and UPLC-QTOF/MSE techniques assisted by UNIFI information system
Fármacos Catalyst-Free Conjugate Addition of Indolizines to In Situ-Generated Oxidized Morita-Baylis-Hillman Adducts
Fármacos Synthesis of 1,4,6-Tricarbonyl Compounds via Regioselective Gold(I)-Catalyzed Alkyne Hydration and Their Application in the Synthesis of alpha-Arylidene-butyrolactones
Biodiversidade, Fármacos The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl
Fármacos Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus
Biodiversidade Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging
Biodiversidade, Fármacos Meliponamycins: Antimicrobials from Stingless Bee-Associated Streptomyces sp
Biodiversidade, Fármacos Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach
Biodiversidade, Fármacos Structure-Based Virtual Screening, Molecular Dynamics and Binding Free Energy Calculations of Hit Candidates as ALK-5 Inhibitors
Biodiversidade, Fármacos Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi
Fármacos Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors
Fármacos SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells
Biodiversidade, Fármacos Antimicrobial and Antibiofilm Activity of Lys-[Trp6]hy-a1 Combined with Ciprofloxacin Against Gram-Negative Bacteria
Biodiversidade, Fármacos Antioxidant and Antibacterial Activity of Sulfonamides Derived from Carvacrol: A Structure-Activity Relationship Study
Biodiversidade, Fármacos Molecular Docking and Quantum Studies of Lawsone Dimers Derivatives: New Investigation of Antioxidant Behavior and Antifungal Activity
Fármacos Preparation of tetrahydro-1H-xanthen-1-one and chromen-1-one derivatives via a Morita-Baylis-Hillman/oxa-Michael/elimination cascade
Biodiversidade QSAR studies on benzothiophene derivatives as Plasmodium falciparum N‐myristoyltransferase inhibitors: Molecular insights into affinity and selectivity
Biodiversidade CYP712K4 Catalyzes the C-29 Oxidation of Friedelin in the Maytenus ilicifolia Quinone Methide Triterpenoid Biosynthesis Pathway
Fármacos Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti
Fármacos Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi
Fármacos Modeling Studies for the DisStructure-Based and Molecularcovery of Cyclic Imides as Reversible Cruzain Inhibitors With Potent Anti-Trypanosoma cruzi Activity
Fármacos Enantioselective Heck Arylation of Acyclic Alkenol Aryl Ethers: Synthetic Applications and DFT Investigation of the Stereoselectivity
Fármacos Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies
Biodiversidade Antimicrobial and antibiofilm activities of Casearia sylvestris extracts from distinct Brazilian biomes against Streptococcus mutans and Candida albicans
Fármacos Iron-Catalyzed Meerwein Carbooxygenation of Electron-Rich Olefins: Studies with Styrenes, Vinyl Pyrrolidinone, and Vinyl Oxazolidinone
Fármacos Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis
Fármacos Computational methods for NMR and MS for structure elucidation II: database resources and advanced methods
Fármacos Natural deep eutectic solvents and aqueous solutions as an alternative extraction media for propolis
Fármacos Unveiling the binding and orientation of the antimicrobial peptide Plantaricin 149 in zwitterionic and negatively charged membranes
Fármacos Maytenin Plays a Special Role in the Regulation of the Endophytic Bacillus megaterium in Peritassa campestris Adventitious Roots
Biodiversidade Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani
Fármacos SSi6 promotes cell death by apoptosis through cell cycle arrest and inhibits migration and invasion of MDA-MB-231 human breast cancer cells
Biodiversidade Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human Neonatal Foreskin Fibroblasts in vitro and Collagen Deposition
Fármacos Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents
Biodiversidade Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis – Falkenbergia stage
Biodiversidade PHYTOTOXIC CONSTITUENTS FROM ENDOPHYTIC FUNGUS Xylaria cubensis ASSOCIATED WITH Eugenia brasiliensis
Fármacos Improvement of bioactive metabolite production in microbial cultures—A systems approach by OSMAC and deconvolution‐based 1HNMR quantification
Fármacos In vitro Antiplasmodial Activities of Alkaloids Isolated from Roots of Worsleya procera (Lem.) Traub (Amaryllidaceae)
Fármacos Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases
Biodiversidade Combined use of tandem mass spectrometry and computational chemistry to study 2H‐chromenes from Piper aduncum
Fármacos Organocatalytic asymmetric vinylogous 1,4-addition of α,α-Dicyanoolefins to chalcones under a bio-based reaction media: Discovery of new Michael adducts with antiplasmodial activity
Fármacos Quantitative Structure–Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity
Fármacos Palladium-Mediated Oxidative Annulation of δ-Indolyl-α,β-Unsaturated Compounds toward the Synthesis of Cyclopenta[b]indoles and Heterogeneous Hydrogenation To Access Fused Indolines
Fármacos Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis
Fármacos Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)
Biodiversidade Ecological Insights to Track Cytotoxic Compounds among Maytenus ilicifolia Living Individuals and Clones of an Ex Situ Collection
Biodiversidade Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam
Fármacos Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents
Biodiversidade Chemical Space and Diversity of the NuBBE Database: A Chemoinformatic Characterization
Biodiversidade Dimerization of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity
Biodiversidade Dimeric chalcones derivatives from Myracrodruon urundeuva act as cathepsin V inhibitors
Fármacos In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide
Biodiversidade Using natural deep eutectic solvents for the extraction of metabolites in Byrsonima intermedia leaves
Fármacos Enantioselective Synthesis of Phthalides and Isochromanones viaHeck–Matsuda Arylation of Dihydrofurans
Biodiversidade Self-association and folding in membrane determine the mode of action of peptides from the lytic segment of sticholysins
Fármacos GA-Hecate antiviral properties on HCV whole cycle represent a new antiviral class and open the door for the development of broad spectrum antivirals
Biodiversidade, Fármacos Phthalimide Derivatives with Bioactivity against Plasmodium falciparum: Synthesis, Evaluation, and Computational Studies Involving bc1Cytochrome Inhibition
Fármacos Daptomycin and vancomycin heteroresistance revealed among CC5-SCCmecII MRSA clone and in vitro evaluation of treatment alternatives
Biodiversidade Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds
Biodiversidade Dissecting the mechanism of action of actinoporins. Role of the N-terminal amphipathic alpha-helix in membrane binding and pore activity of sticholysins I and II
Biodiversidade, Fármacos Quinoxaline derivatives as potential antitrypanosomal and antileishmanial agents
Fármacos Enantioselective, Noncovalent, Substrate-Directable Heck-Matsuda and Oxidative Heck Arylations of Unactivated Five-Membered Carbocyclic Olefins
Fármacos Chiral N,NLigands Enabling Palladium-Catalyzed Enantioselective Intramolecular Heck-Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions
Fármacos Resistance in In Vitro Selected Tigecycline-Resistant Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Is Driven by Mutations in mepR and mepA Genes
Biodiversidade Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colletotrichum crassipes and Xylaria sp., and Their Antifungal, Antioxidant and Anticholinesterase Activities
Fármacos Molecular Cloning and Biochemical Characterization of Iron Superoxide Dismutase from Leishmania braziliensis
Fármacos Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography—searching for alternatives to organic solvents
Biodiversidade A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway
Biodiversidade Discovery of Marinoquinolines as Potent and Fast-Acting Plasmodium falciparum Inhibitors with In Vivo Activity
Biodiversidade Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria
Biodiversidade Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae)
Biodiversidade, Fármacos LmrBPP9: A synthetic bradykinin-potentiating peptide from Lachesis muta rhombeata venom that inhibits the angiotensin-converting enzyme activity in vitro and reduces the blood pressure of hypertensive rats
Biodiversidade Thermoanalytical and spectroscopic characteristics of young and old leaves powder and methanolic extracts of Niedenzuella multiglandulosa
Biodiversidade, Fármacos In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide
Biodiversidade Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum
Biodiversidade, Fármacos Dereplication by HPLC‐DAD‐ESI‐MS/MS and Screening for Biological Activities of Byrsonima Species (Malpighiaceae)
Biodiversidade, Fármacos Can an Alcohol Act As an Acid/Base Catalyst in Water Solution? An Experimental and Theoretical Study of Imidazole Catalysis of the Aqueous Morita-Baylis–Hillman Reaction
Biodiversidade, Fármacos Amphotericin B as an inducer of griseofulvin-containing guttate in the endophytic fungus Xylaria cubensis FLe9
Biodiversidade, Fármacos Electrochemical sensor for dodecyl gallate determination based on electropolymerized molecularly imprinted polymer
Biodiversidade, Fármacos Endophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae)
Biodiversidade, Fármacos Short and Diastereoselective Total Synthesis of the Polyhydroxylated Pyrrolidine LAB-1: A Potent α-Glycosidase Inhibitor
Biodiversidade, Fármacos Asymmetric synthesis and evaluation of epoxy-α-acyloxycarboxamides as selective inhibitors of cathepsin L
Biodiversidade, Fármacos Asymmetric synthesis of new gamma-butenolides via organocatalyzed epoxidation of chalcones
Biodiversidade NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
Biodiversidade, Fármacos Proteome profiling reveals insights into secondary metabolism in Maytenus ilicifolia (Celastraceae) cell cultures producing quinonemethide triterpenes
Biodiversidade, Fármacos Molecular inter-kingdom interactions of endophytes isolated from Lychnophora ericoides
Biodiversidade, Fármacos Impairment of the class IIa bacteriocin receptor function and membrane structural changes are associated to enterocin CRL35 high resistance in Listeria monocytogenes
Biodiversidade, Fármacos Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation
Biodiversidade ONE STRAIN-MANY COMPOUNDS (OSMAC) METHOD FOR PRODUCTION OF PHENOLIC COMPOUNDS USING Camarops sp., AN ENDOPHYTIC FUNGUS FROM Alibertia macrophylla (Rubiaceae)
Biodiversidade, Fármacos Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration
Biodiversidade, Fármacos Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene
Biodiversidade, Fármacos Parceria entre USP e UNESP produz a primeira base de dados de produtos naturais do Brasil
